Logo-jpe
Submitted: 15 Aug 2018
Accepted: 09 Feb 2019
ePublished: 14 Apr 2019
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)

J Prev Epidemiol. 2019;4(1): e07.
  Abstract View: 2283
  PDF Download: 1239

Letter to Editor

Metformin and kidney protection; a letter to editor on recent findings

Sahar Koushki 1, Reza Mohammadrezaei Khorramabadi 1, Peyman Amanolahi Baharvand 2, Amin Hasanvad 3* ORCID logo

1 Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran
2 Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
3 Nutritional Health Research Center, Department of Pharmacology and ،oxicology, Faculty of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran
*Corresponding Author: Correspondence to: Amin Hasanvand, PhD; Email: , Email: dr.hasanvand@yahoo.com

Abstract

The mechanism of metformin includes the enhancement of skeletal muscles and adipocytes glucose uptake, and inhibiting the production of glucose in liver. AMP-activated protein kinase (AMPK) via metformin, a cellular energy regulator, can be used to balance hemostasis. Treatment with metformin in glomerular mesangial cells (MCs) in a diabetic situation has resulted in the significant increase of superoxide dismutase (SOD) and malondialdehyde (MDA), monocyte chemoattractant protein-1 (MCP-1), p38 mitogen-activated protein kinase (p38MAPK) expression, the expression of nuclear factor-κB (NF-κB), intracellular p22phox mRNA and protein level, intercellular adhesion molecule-1 (ICAM-1), proinflammatory cytokines, transforming growth factor-beta 1 (TGF-β1) and ROS production suppression and lipid peroxidation. Metformin also has a reno-protective mechanism, i.e., restoring mitochondrial function integrity.

 Citation: C. Koushki S, Mohammadrezaei Khorramabadi R, Amanolahi Baharvand P, Hasanvand A. Metformin and kidney protection; a letter to editor on recent findings. J Prev Epidemiol. 2019;4(1):e07. 
First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 2284

Your browser does not support the canvas element.


PDF Download: 1239

Your browser does not support the canvas element.