Submitted: 15 Aug 2018
Accepted: 09 Feb 2019
First published online: 14 Apr 2019
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J Prev Epidemiol. 2019;4(1):e07-e07.
  Abstract View: 127
  PDF Download: 90

Letter to Editor

Metformin and kidney protection; a letter to editor on recent findings

Sahar Koushki 1, Reza Mohammadrezaei Khorramabadi 1, Peyman Amanolahi Baharvand 2, Amin Hasanvad 3 * ORCiD

1 Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran
2 Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
3 Nutritional Health Research Center, Department of Pharmacology and ،oxicology, Faculty of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran
Correspondence to: Amin Hasanvand, PhD; Email: Email: dr.hasanvand@yahoo.com

Abstract

The mechanism of metformin includes the enhancement of skeletal muscles and adipocytes glucose uptake, and inhibiting the production of glucose in liver. AMP-activated protein kinase (AMPK) via metformin, a cellular energy regulator, can be used to balance hemostasis. Treatment with metformin in glomerular mesangial cells (MCs) in a diabetic situation has resulted in the significant increase of superoxide dismutase (SOD) and malondialdehyde (MDA), monocyte chemoattractant protein-1 (MCP-1), p38 mitogen-activated protein kinase (p38MAPK) expression, the expression of nuclear factor-κB (NF-κB), intracellular p22phox mRNA and protein level, intercellular adhesion molecule-1 (ICAM-1), proinflammatory cytokines, transforming growth factor-beta 1 (TGF-β1) and ROS production suppression and lipid peroxidation. Metformin also has a reno-protective mechanism, i.e., restoring mitochondrial function integrity.
 Citation: C. Koushki S, Mohammadrezaei Khorramabadi R, Amanolahi Baharvand P, Hasanvand A. Metformin and kidney protection; a letter to editor on recent findings. J Prev Epidemiol. 2019;4(1):e07. 
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