Submitted: 23 Feb 2017
Accepted: 09 Apr 2017
First published online: 14 Apr 2017
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J Prev Epidemiol. 2017;2(2):e01-.
  Abstract View: 235
  PDF Download: 207

Case Report

Membranous nephropathy with inferior vena cava and renal vein thrombosis 

Zain Majid 1 * , Saima Ahmed 1, Tajammul Waqar 1, Shoaib Ahmed 1, Raja Taha Yaseen Khan 1, Muhammad Mubarak 2

1 Department of Internal Medicine
2 Department of Histopathology, Sindh Institute of Urology and Transplantation (SIUT), Karachi, Pakistan
3 Department of Histopathology, Sindh Institute of Urology and Transplantation (SIUT), Karachi, Pakistan
Correspondence to: Zain Majid Email: Zain88@Hotmail.com

Abstract

A biopsy proven membranous nephropathy female came to the hospital with fever and bilateral lumbar pain. There were no urinary or respiratory symptoms. The workup revealed a creatinine of 1.4 mg/dL, low serum albumin and 3+proteins in the urine. Her erythrocyte sedimentation rate (ESR) was raised and her serology showing a C3 and C4 of complements of 2.24 and 0.41 respectively. Notably, antinuclear antibody (ANA) was strongly positive, anti-dsDNA was negative. Ultrasonography showed slight echogenic kidneys with a hematoma seen in her left kidney. Then a CT scan of chest, abdomen and pelvis was planned that revealed enlarged and swollen kidneys having indistinct cortico-medullary junction and a partial thrombus in the inferior vena cava (IVC) and the renal veins. Antiphospholipid antibodies serology and D-dimer levels were unremarkable. She was given streptokinase infusion that resulted in recovery of her renal functions and later on kept on lifelong warfarin.
Citation: Majid Z, Ahmed S, Waqar T, Ahmed S, Yaseen Khan RT, Mubarak M. Membranous nephropathy with inferior vena cava and renal vein thrombosis.  J Prev Epidemiol. 2017;2(2):e01. DOI: 10.15171/jpe.2017.01.
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