Submitted: 08 Feb 2017
Accepted: 27 Jun 2017
First published online: 15 Jul 2017
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J Prev Epidemiol. 2018;3(1):e03-.
doi: 10.15171/jpe.2018.03
  Abstract View: 174
  PDF Download: 176

Original

Impact of uncontrolled glycosylated hemoglobin on contrast-induced acute kidney injury in patients with type 2 diabetes mellitus undergoing percutaneous coronary intervention 

Emad Abdallah 1 * , Ahmed Ali 2, Ahmed Abdullah 3

1 Department of Nephrology, Theodor Bilharz Research Institute, Cairo, Egypt
2 Department of Intensive Care Unit, Theodor Bilharz Research Institute, Cairo, Egyp
3 Department of Cardiology, National Heart Institute, Cairo, Egypt
Correspondence to: Emad Abdallah Email: drabdallah96@gmail.com

Abstract

Introduction: Numerous studies revealed that hyperglycemia in patients undergoing percutaneous coronary intervention (PCI) increases the risk of acute kidney injury (AKI) in hospital admission individuals. However, there is a little data regarding the effect of long-standing hyperglycemia on the presence of AKI in patients with myocardial infarction undergoing primary PCI.

Objectives: In this study, we investigated the effect of chronic poor glycemic control (using HbA1c, as an index of glucose control in the last 2-3 months) on AKI occurrence in individuals with type 2 diabetes mellitus (T2DM) and ST-elevation myocardial infarction (STEMI) undergoing coronary angiography and primary PCI.

Patients and Methods: We prospectively studied 120 patients with T2DM and STEMI undergoing primary PCI. According to glycosylated hemoglobin (HbA1c), individuals were divided into two groups, patients with HbA1c<7% (group 1, n = 47) and patients with HbA1c ≥ 7% (group 2, n = 73). Medical records of both groups were reviewed for the occurrence of AKI.

Results: AKI was found in 3 of 47 patients (6.38%) in group 1 and in 16 of 73 patients (21.9%) in group 2 (P = 0.043). There was no statistically difference in baseline serum creatinine and estimated glomerular filtration rate between the two groups. Group 2 had significantly higher HbA1c (8.6 ±1.6 vs. 5.8 ±1.2 %; P = 0.001) and higher admission glucose levels (259 ± 95 mg/dL vs. 163 ± 71 mg/dL; P = 0.001)

Conclusion: Elevated HbA1c was associated with higher risk of AKI in T2DM with STEMI who treated with primary PCI.

Citation: Abdallah E, Ali A, Abdullah A. Impact of uncontrolled glycosylated hemoglobin on contrast-induced acute kidney injury in patients with type 2 diabetes mellitus undergoing percutaneous coronary intervention. J Prev Epidemiol. 2017;3(1):e03. DOI: 10.15171/jpe.2018.03.
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