Submitted: 13 Feb 2018
Accepted: 09 Jun 2018
First published online: 14 Jul 2018
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J Prev Epidemiol. 2018;3(2):e03-e03.
  Abstract View: 27
  PDF Download: 25

Original

The association between G\A455 and C\A148 polymorphisms with beta fibrinogen gene and presence of coronary artery disease among Iranian population 

Maedeh Motavas 1, Mohammad Shojaee 2, Davar Aldavood 3 *

1 Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran
2 Department of Internal Cardiovascular Medicine, Jahrom University of Medical Sciences, Jahrom, Iran
3 Department of Cardiovascular. Shiraz University of Medical Sciences, Shiraz Iran
Correspondence to: Davar Aldavood, Email: Email: d.aldavood.cardio@gmail.com

Abstract

Introduction: The polymorphisms of beta-fibrinogen gene are now suggested to affect plasma fibrinogen levels and the risk for coronary artery disease (CAD). Objectives: The present study aimed to evaluate the association between the two polymorphisms of G\ A455 and C\A148 with beta fibrinogen gene and the increased risk for premature CAD among a sample of Iranian population.

Patients and Methods: This case-control association study was conducted on 100 consecutive patients suffering premature coronary artery disease as the cases and 100 healthy individuals without any evidence of coronary involvement. Patients were randomly selected and adjusted for gender and age. Determining different genotypic patterns of the G\A455 and C\A148 SNPs were carried out by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis.

Results: The mean level of serum fibrinogen was 354.32±93.85 mg/dL in the case group and 303.43 ± 84.51 mg/dL in the control group, indicating the abnormally increased level of fibrinogen in 68% and 30% respectively with a significant difference (P<0.001). Overall, the mean level of fibrinogen was significantly higher in the smoker group than in the non-smoker group (P=0.032). Regarding the frequency of C/T148 alleles, in the case group, 82% had C allele and 18% had T allele of the polymorphisms. The rate of these alleles in the control group was 83% and 17% respectively with no significant difference (P=0.852). Similarly, the frequency of the alleles A and G of G\A455 polymorphism was 87% and 13% in the case group and 89% and 11% in the control group respectively with no significant difference (P=0.663).

Conclusion: There is no association between G\A455 and C\A148 polymorphisms with beta-fibrinogen gene and presence of CAD. However, the increased level of serum fibrinogen can effectively predict CAD.

Citation: Motavas M, Shojaee M, Aldavood D. The association between G\A455 and C\ A148 polymorphisms with beta fibrinogen gene and presence of coronary artery disease among Iranian population. J Prev Epidemiol. 2018;3(2):e03. 

 

 

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