Submitted: 07 Aug 2018
Accepted: 23 Oct 2018
First published online: 07 Dec 2018
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J Prev Epidemiol. 2018;3(2):E17-E17.
  Abstract View: 87
  PDF Download: 58

Brief Report

TM6SF2 E167K variant and deterioration on hepatitis disease and hepatocellular carcinoma; a molecular explanation

Sora Yasri 1 * , Viroj Wiwanitkit 2

1 KMT Primary Care Center, Bangkok Thailand
2 Honorary professor, Dr. D.Y. Patil University, Pune, India
Correspondence to: Sora Yasri, Email: Email: sorayasri@outlook.co.th

Abstract

Hepatic disorder is a common problem in medicine. The serious liver diseases such as hepatitis and hepatocellular carcinoma are the present public health problem worldwide. The effect of genetic background on the liver disease severity is very interesting. Of several genetic underlying factors, the TM6SF2 polymorphism is widely mentioned of the clinical importance. The existence of TM6SF2 E167K variant is reported for the relationship with the severity of hepatitis and hepatocellular carcinoma diseases. In this article, the authors perform a molecular structure analysis by standard quantum calculation technique. The molecular change in the TM6SF2 E167K variant is observed and can explained for the deterioration of liver diseases seen in this genetic variant
 Citation: Yasri S, Wiwanitkit V. TM6SF2 E167K variant and deterioration on hepatitis disease and hepatocellular carcinoma; a molecular explanation. J Prev Epidemiol. 2018;3(2):e17. 
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