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Submitted: 03 Nov 2020
Accepted: 24 Dec 2020
ePublished: 29 Dec 2020
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J Prev Epidemiol. 2020;5(2): e27.
doi: 10.34172/jpe.2020.27
  Abstract View: 49
  PDF Download: 19

Original

The concordance of endoscopic and histologic findings of 530 pediatric patients suspicious for celiac disease in a referral center, Isfahan, Iran

Azar Naimi 1 ORCID logo, Azar Baradaran 1 ORCID logo, Elahe Pirpiran 1 ORCID logo, Peiman Nasri 2 ORCID logo, Masoud Akhlaghi 1 * ORCID logo

1 Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Pediatrics, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Introduction: The purpose of this study is evaluation of concordance of histologic and endoscopic findings in pediatrics referred to Imam Hossein children’s hospital, in Isfahan for evaluation of celiac disease. An accurate prediction of the likelihood of a histologic finding in the setting of a visually normal endoscopy can help prepare families for unanticipated results.

Patients and Methods: This is a retrospective study conducted from 2015-2017. The sampling method is census and all eligible patients are included in the study. At the beginning of the work, obtaining consent for entering the project has been done through interviews. After that, patients information such as file number, age and gender according to the file were entered into the data gathering sheet. Data were analyzed using SPSS software version 22. Pvalue< 0.05 was considered significant.

Results: Around 530 patients suspected of having celiac disease participated in the present study. The mean age of the subjects was 6.88 ± 4.31 years. Among them, 57.6% (305 patients) were girls and 42.4% (225 patients) were boys. According to the results, the kappa agreement coefficient is equal to 0.42. There was moderate agreement between endoscopy and pathology findings (kappa = 0.42).

Conclusion: The results of the study and the kappa Cohen coefficient indicate the appropriateness of using endoscopy in patients with suspected celiac disease.

Keywords: Endoscopic, Celiac disease, Children
Citation: Naimi A, Baradaran A, Pirpiran E, Nasri P, Akhlaghi M. The concordance of endoscopic and histologic findings of 530 pediatric patients suspicious for celiac disease in a referral center, Isfahan, Iran. J Prev Epidemiol. 2020;6(2):e27. doi: 10.34172/jpe.2020.27.
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