Abstract
Introduction: Systemic lupus erythematosus (SLE) is an autoimmune disease whose occurrence or exacerbation is associated with various factors.
Objectives: The aim of the present study was to investigate the prevalence of different types of blood groups in SLE patients and the relationship between the disease activity of SLE and various blood groups.
Patients and Methods: This cross-sectional study was performed on 146 patients with SLE from February 2015 to October 2017. The score of disease activity was determined by SLEDAI-2K 10 days (SLE disease activity index-2K) and the blood type of all patients was determined.
Results: The most common blood type in patients studied was O blood group and then A, B and AB, respectively. The mean SLEDAI-2K scores in blood groups of A and B were significantly higher than blood groups of AB and O. The mean SLEDAI-2K score in blood group A was significantly different from non-A group (P = 0.016), however no significant difference between group B and non-B was seen. The mean score of the disease in blood group O is significantly lower than other blood groups (P = 0.005). Additionally, patients with Rh + had a significantly higher score than patients with Rh- (P = 0.019).
Conclusion: Since the SLEDAI in blood groups A and B is higher than the other two blood groups, in the face of aggravating factors, SLE patients with these blood groups need more care and attention.