Submitted: 18 Feb 2017
Accepted: 02 Apr 2017
ePublished: 14 Apr 2017
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)

J Prev Epidemiol. 2017;2(2): e09.
  Abstract View: 569
  PDF Download: 535


Molecular signaling pathways of diabetic kidney disease; new concepts 

Esmat Aghadavoud 1, Hamid Nasri 2, Masoud Amiri 3,4 *

1 Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
2 Nickan Research Institute, Isfahan, Iran
3 Department of Epidemiology and Biostatistics, Shahrekord University of Medical Sciences, Shahrekord, Iran
4 Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
Correspondence to: Masoud Amiri


Diabetic kidney disease is a main cause of end-stage renal disease (ESRD), therefore, it is important to understand the molecular mechanism underlying diabetic kidney disease. Todays, various factors such as hemodynamic changes, molecular signaling and metabolic pathways have been shown to be involved in its pathogenesis. Excessive glucose influx stimulates cellular signaling pathways, containing advanced glycation end-products (AGEs), oxidative stress conditions, Rho-kinase, the diacylglycerol (DAG)-protein kinase C (PKC) pathway, polyol pathway and hexosamine pathway. In hyperglycemic condition, these factors cooperate with other aggravating factors. Then activated inflammatory processes lead to the development of glomerulosclerosis. The aim is to describe understanding of the signaling pathways in diabetic kidney disease. 
Keywords: Diabetic nephropathy, Signaling pathways, Metabolic pathway Metabolic pathway, End-stage renal disease, Diabetic kidney disease, Type II diabetes mellitus
Citation: Aghadavoud E, Nasri H, Amiri M. Molecular signaling pathways of diabetic kidney disease; new concepts.  J Prev Epidemiol. 2017;2(2):e03. DOI: 10.15171/jpe.2017.03.
First Name
Last Name
Email Address
Security code

Abstract View: 569

Your browser does not support the canvas element.

PDF Download: 535

Your browser does not support the canvas element.