Submitted: 19 Jan 2017
Accepted: 14 Apr 2017
ePublished: 29 Apr 2017
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J Prev Epidemiol. 2017;2(2): e11.
  Abstract View: 666
  PDF Download: 392


Impact of proton pump inhibitors on renal function and structure; new concepts 

Mahrang Hedaiaty 1, Arman Amiri 2, Masoud Amiri 3,4 *

1 Fatemieh Hospital, Hamadan University of Medical Sciences, Hamadan, Iran
2 Wolfert van Borselen, Rotterdam, The Netherlands
3 Department of Epidemiology and Biostatistics, School of Health, Shahrekord University of Medical Sciences, Shahrekord, Iran
4 Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
Correspondence to: Masoud Amiri, Ph.D


Proton pump inhibitors (PPIs) such as omeprazole, pantoprazole, esomeprazole and lansoprazole are the most popular therapies for reflux disease and heartburn. Applications of PPIs are commonly safe and well-accepted by physicians, with an adverse effect occurring at a rate of about three percent. The common side effects are dizziness, constipation, headaches, diarrhea and cutaneous responses. PPIs can influence in all cells of body that are related to deadly diseases such as heart attacks, kidney disease and dementia. Some research studies have found that PPIs were related to an inflammatory process in the kidneys as acute interstitial nephritis. This review will emphasis on conducted researches about adverse effects of PPIs on the kidney. 
Keywords: Proton pump inhibitors, Kidney, Acute interstitial nephritis, Side effect, Omeprazole, Pantoprazole
Citation: Hedaiaty M, Amiri A, Amiri A. Impact of proton pump inhibitors on renal function and structure; new concepts. J Prev Epidemiol. 2017;2(2):e05. DOI: 10.15171/jpe.2017.05.
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