Submitted: 03 Aug 2019
Accepted: 20 Nov 2019
ePublished: 07 Dec 2019
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J Prev Epidemiol. 2019;4(2): e14.
  Abstract View: 118
  PDF Download: 51

Case Report

Bi-lineage acute leukemia; a case with B-lymphoblasts and myeloid blasts 

Esmaeil Shahabi Satlsar 1 ORCID logo, Farahnaz Ghahremanfard 2 * ORCID logo, Mohammad Moslehabadi Farahani 4, Anahid Nabavi 3

1 Takhte Tavous Pathobiology Laboratory, Flow Cytometry Department, Tehran, Iran
2 Cancer Research Center, Semnan University of Medical Sciences, Semnan, Iran
3 Rasad Pathobiology Laboratory, Flow cytometry Department, Tehran, Iran
4 Faculty of Dentistry, Semnan University of Medical Sciences, Semnan, Iran

Abstract

Mixed phenotypic acute leukemia (MPAL) is classified under acute leukemia of ambiguous lineage. Most reported cases of acute ambiguous leukemia belong to bi-phenotypic leukemia. However, bi-lineage leukemia is rare. A 57-year-old male was admitted with weakness and weight loss since one month ago. He suffered from anorexia. In admission time he was pale and cachectic. Lymphadenopathy and splenomegaly were not seen. In laboratory tests, the complete blood counts revealed normal limit leukocytes, anemia, and thrombocytopenia. Bone marrow aspiration showed 60% blasts. Immunophenotyping showed a dual population of blasts which expressed CD19, CD10, CD22, TDT and CD13, CD33 and cMPO. Thus, flow cytometric immunophenotyping helped to establish a final diagnosis of MPAL; B/myeloid bi-lineage leukemia. 
Keywords: Acute leukemia, Myeloperoxidase staining, Acute ambiguous leukemia, Lymphadenopathy, Splenomegaly

Citation: Shahabi Satlsar E, Ghahremanfard F, Mosleh M, Nabavi A. Bilineage acute leukemia; a case with B-lymphoblasts and myeloid blasts. J Prev Epidemiol. 2019;4(2):e14

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