Membranous nephropathy with inferior vena cava and renal vein thrombosis

Zain Majid, Saima Ahmed, Tajammul Waqar, Shoaib Ahmed, Yaseen Khan Raja Taha, Muhammad Mubarak



A biopsy proven membranous nephropathy female came to the hospital with fever and bilateral lumbar pain. There were no urinary or respiratory symptoms. The workup revealed a creatinine of 1.4 mg/dL, low serum albumin and 3+proteins in the urine. Her erythrocyte sedimentation rate (ESR) was raised and her serology showing a C3 and C4 of complements of 2.24 and 0.41 respectively. Notably, antinuclear antibody (ANA) was strongly positive, anti-dsDNA was negative. Ultrasonography showed slight echogenic kidneys with a hematoma seen in her left kidney. Then a CT scan of chest, abdomen and pelvis was planned that revealed enlarged and swollen kidneys having indistinct cortico-medullary junction and a partial thrombus in the inferior vena cava (IVC) and the renal veins. Antiphospholipid antibodies serology and D-dimer levels were unremarkable. She was given streptokinase infusion that resulted in recovery of her renal functions and later on kept on lifelong warfarin.

Core tip
Thrombus in the IVC is a rare incidence in membranous nephropathy.


Citation: Majid Z, Ahmed S, Waqar T, Ahmed S, Yaseen Khan RT, Mubarak M. Membranous nephropathy with inferior vena cava and renal vein thrombosis. J Prev Epidemiol. 2017;2(2):e01.


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