Molecular signaling pathways of diabetic kidney disease; new concepts

Esmat Aghadavoud, Hamid Nasri, Masoud Amiri

Abstract


Diabetic kidney disease is a main cause of end-stage renal disease (ESRD), therefore, it is important to understand the molecular mechanism underlying diabetic kidney disease. Todays, various factors such as hemodynamic changes, molecular signaling and metabolic pathways have been shown to be involved in its pathogenesis. Excessive glucose influx stimulates cellular signaling pathways, containing advanced glycation end-products (AGEs), oxidative stress conditions, Rho-kinase, the diacylglycerol (DAG)-protein kinase C (PKC) pathway, polyol pathway and hexosamine pathway. In hyperglycemic condition, these factors cooperate with other aggravating factors. Then activated inflammatory processes lead to the development of glomerulosclerosis. The aim is to describe understanding of the signaling pathways in diabetic kidney disease.

 

Core tip
Excessive glucose influx stimulates cellular signaling pathways, including advanced glycation end-products (AGEs), oxidative stress conditions, Rho-kinase, the diacylglycerol (DAG)-protein kinase C (PKC) pathway, polyol pathway and hexosamine pathway. In hyperglycemic condition, these factors cooperate with other aggravating factors.Then activated inflammatory processes lead to development of glomerulosclerosis.

 

Citation: Aghadavoud E, Nasri H, Amiri M. Molecular signaling pathways of diabetic kidney disease; new concepts. J Prev Epidemiol. 2017;2(2):e03.


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Creative Commons Attribution 4.0 License
 This work is licensed under a Creative Commons Attribution 4.0 License.

Copyright © 2017 The Author(s); Published by Society of Diabetic Nephropathy Prevention.
 
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