Impact of proton pump inhibitors on renal function and structure; new concepts

Mahrang Hedaiaty, Arman Amiri, Masoud Amiri


Proton pump inhibitors (PPIs) such as omeprazole, pantoprazole, esomeprazole and lansoprazole are the most popular therapies for reflux disease and heartburn. Applications of PPIs are commonly safe and well-accepted by physicians, with an adverse effect occurring at a rate of about three percent. The common side effects are dizziness, constipation, headaches, diarrhea and cutaneous responses. PPIs can influence in all cells of body that are related to deadly diseases such as heart attacks, kidney disease and dementia. Some research studies have found that PPIs were related to an inflammatory process in the kidneys as acute interstitial nephritis. This review will emphasis on conducted researches about adverse effects of PPIs on the kidney.


Core tip
Proton pump inhibitors (PPIs) are extensively recommended as the best treatment for acid-related gastrointestinal diseases; nevertheless, the safety of long-term PPIs administration still need serious prospective examination.


Citation: Hedaiaty M, Amiri A, Amiri A. Impact of proton pump inhibitors on renal function and structure; new concepts. J Prev Epidemiol. 2017;2(2):e05.





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Copyright © 2017 The Author(s); Published by Society of Diabetic Nephropathy Prevention.
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Journal of Preventive Epidemiology follows;