Submitted: 29 Sep 2019
Accepted: 10 Nov 2019
ePublished: 18 Dec 2019
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J Prev Epidemiol. 2019;4(2): e27.
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  PDF Download: 489


Mechanisms of Helicobacter pylori-induced gastric mucosal injury

Mohammad Bahadoram 1,2, Bijan Keikhaei 2, Mohammad-Reza Mahmoudian-Sani 2, Kosar Alikhani 2, Motahareh Motiee 2, Ammar Helalinasab 2, Maedeh Barahman 1*

1 Department of Radiation Oncology, Firoozgar Hospital, Firoozgar Clinical Research Development Center (FCRDC), Iran University of Medical Sciences (IUMS), Tehran, Iran
2 Thalassemia and Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
*Corresponding Author: Correspondence to: Maedeh Barahman, Email: maedeh.barahman@gmail.com, , Email: brahman.m@iums.ac.ir


Helicobacter pylori is a common pathogenic microorganism which is able to colonize in harsh acidic environment of the stomach. It also plays an important role in developing gastric cancer (GC) by causing inflammation, epigenetic changes in cancer-related genes, and disturbance in life cycle of cells. Besides, GC is the fourth most common cause of cancer-related mortality in the world. There is still no consensus regarding the eradication of H. pylori and its effects in terms of preventing gastric lesion or atrophy progression. The main purpose of this review was to evaluate factors shaping H. pylori colonization into gastric epithelial cells and then normal gastric mucosa progression to GC.

Citation: Bahadoram M, Keikhaei B, Mahmoudian-Sani MR, Alikhani K, Motiee M, Helalinasab A, Barahman M. Mechanisms of Helicobacter pyloriinduced gastric mucosal injury. J Prev Epidemiol. 2019;4(2):e27.
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