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Submitted: 28 Jan 2016
Accepted: 04 Apr 2016
ePublished: 23 Apr 2016
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J Prev Epidemiol. 2016;1(2): e11-.
  Abstract View: 1620
  PDF Download: 982

Original

Predictors of hemorrhagic complications after ultrasoundguided nonfocal renal biopsy 

Amy Deipolyi 1*, Suvranu Ganguli 2*, Fabio Leonardo 2, Peter F. Hahn 2, Chieh Suai Tan 2, Ashraf Thabet 2, Elkan F. Halpern 2, Peter R. Mueller 2

1 Division of Vascular & Interventional Radiology, Department of Radiology, New York University Medical Center, New York, NY, USA
2 Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
*Corresponding Authors: Correspondence to Amy Deipolyi, Email: amy.deipolyi@nyumc.org; Correspondence to Suvranu Ganguli, Email: sganguli@partners.org

Abstract

Introduction: Ultrasound-guided non-focal renal biopsy (USNFRB) is a well-accepted procedure performed in the renal cortex to investigate medical renal disease or renal transplant rejection.

Objectives: The purpose of this study was to identify the hemorrhagic complication rate for a large cohort of patients after radiologist-performed USNFRB and to identify risk factors.

Patients and Methods: For this Institutional Review Board-approved retrospective review, all patients who underwent USNFRB from January 2001 to September 2012 were identified using a departmental database, and reviewed the electronic chart for demographics, laboratory workup, medications, procedural details, and complications. The impact of these variables on the likelihood of having a bleeding complication that either did (major) or did not (minor) require further intervention was assessed, using Fisher exact and Student’s t tests, and multiple logistic regression.

Results: Of 570 USNFRBs performed by radiologists, 26 (4.6%) resulted in hemorrhagic complications, 15 of which were major and 11 minor. Neither age, gender, race, nor size of biopsy needle differed among patients with and without bleeding complications (P > 0.05). When assessing the impact of coagulation and renal function laboratory measures, low estimated glomerular filtration rate (eGFR) was the strongest predictor of bleeding complication (P = 0.03).

Conclusion: USNFRB is a relatively safe procedure, with less than 5% resulting in bleeding complications. Low eGFR is the strongest predictor of hemorrhagic complication, and is likely the most helpful variable in triaging patients during pre-procedure workup. 


Citation: Deipolyi A, Leonardo F, Hahn PF, Suai Tan C, Thabet A, Halpern EF, Mueller PR, Ganguli S. Predictors of hemorrhagic complications after ultrasound-guided nonfocal renal biopsy.  J Prev Epidemiol. 2016;1(2):e11.
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