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Submitted: 11 Jan 2021
Accepted: 04 Jun 2021
ePublished: 03 Jul 2021
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J Prev Epidemiol. 2021;6(2): e26.
doi: 10.34172/jpe.2021.26
  Abstract View: 54
  PDF Download: 36

Original

Evaluation of the relationship between neutrophil-to-lymphocyte ratio and 25-hydroxy vitamin D levels in hemodialysis patients, Isfahan, Iran

Azar Baradaran 1,2 ORCID logo, Zahra Hoseini 3* ORCID logo, Parin Hedayati 4, Reyhaneh Shirvani 3

1 Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran
2 Infectious Disease and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
3 Faculty of Medicine, Student Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
4 Department of Hemodialysis, Amin Hospital, Isfahan, Iran
Correspondence to: Zahra Hoseini, Email: hoseiniz2020@yahoo.com

Abstract

Introduction: Chronic low-grade inflammation is a comorbid factor in Chronic kidney disease (CKD), and especially in chronic dialysis patients. Recently, neutrophil-to-lymphocyte ratio (NLR), which is very available and affordable, has emerged as an inflammatory index in many disorders such as CKD. Several studies also have shown the anti-inflammatory effects of vitamin D, and scientists believe that we must prevent vitamin D deficiency in CKD patients. Vitamin D supplementation may decrease mortality and morbidity in end-stage renal disease (ESRD) patients.

Objectives: There are few studies on the association between serum 25-hydroxy vitamin D levels and NLR in ESRD patients. Therefore, we tried to evaluate this correlation, hoping to be a key for more researches.

Patients and Methods: We enrolled 140 ESRD hemodialysis patients in a cross-sectional study and evaluated the correlation of NLR with serum 25-hydroxy vitamin D levels and some demographic factors in these patients.

Results: Our results showed a statistically significant negative correlation between NLR and serum 25-hydroxy vitamin D levels (P=0.010, r= -0.216). However, other variables such as disease duration and age had no correlation with NLR (P=0.649, r= - 0.039 and P=0.781, r= - 0.024, respectively). We also used a linear regression test to check any confounder associated with NLR, and the regression was only significant for serum 25-hydroxy vitamin D levels (P=0.011, B=-0.009).

Conclusion: Based on the results, serum 25-hydroxy vitamin D levels can be considered a predictor for NLR in hemodialysis patients.


Keywords: Neutrophil-to-lymphocyte ratio, Vitamin D, End-stage renal disease, Hemodialysis, Inflammation, Inflammatory marker
Citation: Baradaran A, Hoseini Z, Hedayati P, Shirvani R. Evaluation of the relationship between neutrophil-to-lymphocyte ratio and 25-hydroxy vitamin D levels in hemodialysis patients, Isfahan, Iran. J Prev Epidemiol. 2021;6(2):e26. doi: 10.34172/ jpe.2021.26.
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