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Submitted: 03 May 2021
Accepted: 07 Aug 2021
ePublished: 21 Aug 2021
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J Prev Epidemiol. 2021;6(1): e20.
doi: 10.34172/jpe.2021.20
  Abstract View: 352
  PDF Download: 319

Review

Prospective approach to manage COVID-19-related cytokine storm; an updated review on current concepts

Mohaddeseh Bahmani 1 ORCID logo, Lillian Saberian 2* ORCID logo

1 Nickan Research Institute, Isfahan, Iran
2 Independent Researcher and Author, Toronto, Ontario, Canada
*Corresponding Author: Correspondence to: Lillian Saberian, Email: , Email: leilasbrn626@gmail.com

Abstract

Coronavirus disease 2019 or COVID-19, caused by the novel human coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first emerged in late 2019, in the city of Wuhan, Hubei province, China. Unfortunately, despite many efforts to find cures for SARS-CoV-2 disease, still the management of severe cases remains challenging. In severe forms of COVID-19, proinflammatory cytokines are notably elevated (3) and reminiscent of the secondary hemophagocytic lymphohistiocytosis (HLH). According to many studies, immune imbalance and an uncontrolled massive release of inflammatory cytokines have a significant role in COVID-19 severity and ARDS pathophysiology. Accordingly, targeting the over-activated immune system to prevent tissue damage is now one of the most noticed possible strategies to manage severe COVID-19 cases. In the present study, we reviewed studies and clinical trials conducted in this regard.

Citation: Bahmani M, Saberian L. Prospective approach to manage COVID-19-related cytokine storm; an updated review on current concepts. J Prev Epidemiol. 2021;6(1):e20. doi: 10.34172/ jpe.2021.20.
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