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Epidemiology and Prevention
Inhibiting inflammasome; the possible mechanisms of action of azithromycin against COVID-19?
Ali Saeedi-Boroujeni
1 
, Mohammad Bahadoram
2 , Bijan Keikhaei
2, Mohammad-Reza Mahmoudian-Sani
2* , Azadeh Khayyat
3, Mohammad Ali Esmaeilpour
41 Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2 Thalassemia and Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3 Independent Researcher 4246 Graveley St., Burnaby, BC, Canada
4 Advent Health Graduate Medical Education, Center for Collaborative Research, Orlando, FL, USA
Abstract
Cytokine storm and destructive inflammation in the severe form of COVID-19 lead to acute respiratory distress syndrome (ARDS)/acute lung injury (ALI), and dysfunction of several different body organs in patients. SARS-CoV-2 contains all inflammasome-activating proteins belonging to SARS-CoV and MERS-CoV viruses. Macrolides are known to possess immunomodulatory properties. Given the desirable results of azithromycin treatment for patients with a severe case of COVID-19, based on studies, it could be concluded that the immunomodulatory properties of azithromycin to inhibit inflammasome can help the treatment of patients with this disease.
Citation: Saeedi-Boroujeni A, Bahadoram M, Keikhaei B, Mahmoudian-Sani MR, Khayyat A, Esmaeilpour MA. Inhibiting inflammasome; the possible mechanisms of action of azithromycin against COVID-19? J Prev Epidemiol. 2021;6(1):e10. doi: 10.34172/ jpe.2021.10.