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Submitted: 11 Jan 2021
Accepted: 31 May 2021
ePublished: 10 Jul 2021
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J Prev Epidemiol. 2021;6(1): e19.
doi: 10.34172/jpe.2021.19
  Abstract View: 796
  PDF Download: 753

Original

Study of the relationship between neutrophil-to-lymphocyte ratio and parathyroid hormone levels in patients undergoing hemodialysis, Isfahan, Iran

Azar Baradaran 1,2 ORCID logo, Sayed Mohsen Hosseini 3, Reyhaneh Shirvani 4* ORCID logo, Parin Hedayati 5, Zahra Hoseini 4 ORCID logo

1 Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran
2 Infectious Disease and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
3 School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
4 Faculty of Medicine, Student Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
5 Department of Hemodialysis, Amin Hospital, Isfahan, Iran
*Corresponding Author: Correspondence to: Reyhane Shirvani, Email: , Email: reihaneshirvani@rocketmail.com

Abstract

Introduction: Chronic kidney disease (CKD) is a progressive and irreversible disorder that now is introduced as one of the most important problems of general health (1). Serum levels of inflammatory mediators such as C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) elevate in patients with end-stage renal disease (ESRD). Systemic inflammation is correlated with cardiovascular disease. Furthermore, parathyroid hormone (PTH) causes releasing of IL-6 from liver and osteoblast. IL-6 increases lifetime and activity of neutrophils. Therefore, PTH may have a direct correlation with neutrophil-to-lymphocyte ratio (NLR).

Objectives: In this study, we aimed to determine the performance of NLR in hemodialysis and its possible correlation with PTH.

Patients and Methods: This is a cross-sectional study to evaluate the correlation of NLR and serum intact PTH (iPTH), Ca (calcium) and P (phosphorus) and also Ca×P products (mg2 /dL2 ) in a group of stable hemodialysis patients, including male and female gender subgroups, diabetic versus non-diabetic patients, and also patients with or without chronic hypertensive disease.

Results: This study consisted of 136 hemodialysis patients. Our study showed no statistically significant correlation between iPTH (intact parathormone) and NLR in hemodialysis patients (P>0.05). In addition, we test their correlation in other subgroups including hypertensive and normotensive, diabetic and non-diabetics, and male versus female patients. We found no significant correlation between iPTH and NLR in the mentioned subgroups, too.

Conclusion: Observed correlation between PTH and NLR in hemodialysis patients may be due to our small sample size. Therefore, further studies on this subject are suggested.


Citation: Baradaran A, Hosseini SM, Shirvani R, Hedayati P, Hoseini Z. Study of the relationship between neutrophil-to-lymphocyte ratio and parathyroid hormone levels in patients undergoing hemodialysis, Isfahan, Iran. J Prev Epidemiol. 2021;6(1):e19. doi: 10.34172/ jpe.2021.19.
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