Submitted: 02 May 2021
Accepted: 10 Jul 2021
ePublished: 22 Aug 2021
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)

J Prev Epidemiol. 2021;6(2): e22.
doi: 10.34172/jpe.2021.22
  Abstract View: 70
  PDF Download: 39


A study on the relationship of cervical cancer with vaginal microbiota and trichomoniasis infection; a single center study

Pegah Hedayat ORCID logo, Maryam Derakhshan ORCID logo, Reda Bazzal* ORCID logo

1 Department of Pathology, AL-Zahra Hospital, Faculty of Medical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
Correspondence to: Reda Bazzal, Email: bazzal.reda1994@gmail.com


Introduction: Cervical cancer is the most prevalent cancer associated with infection, which is provoked by the human papillomavirus (HPV). Natural vaginal microbes, known as vaginal microbiota, play an important role in regulating vaginal pH and are therefore important in the risk of cervical cancer. Trichomoniasis vaginalis is a genital infection that reports 250 million new infections worldwide each year and can increase the risk of developing cervical cancer in the general population.

Objectives: The aim of this study was to investigate the relationship between cervical cancer and vaginal microbiota or trichomoniasis infection by examining several risk factors.

Patients and Methods: This prospective case study was conducted from 2014 to 2018 from an educational pathology group in Isfahan, 200 samples are included in this study. The groups consist of women over 18 years old. The study group included patients with cervical cancer lesions. For participants, a questionnaire containing information about age, gender, abortion, age at first delivery, smoking or passive smoking and the result of Pap smear test (HPV, vaginal microbiota or Trichomonas) was completed.

Results: Results suggested that cancerous and precancerous lesion development is not associated with parity, age at first child’s birth. However, it is statistically associated with lower vaginal microbiota, increased Trichomonas infection, old age, increased abortion rate, smoking, and the presence of HPV infection on Pap smear.

Conclusion: Protection from harmful factors that affect a healthy vaginal microbiome, such as Trichomonas infections, can reduce the risk of cervical cancer.

Keywords: Cervical cancer, Vaginal microbiota, Trichomoniasis vaginalis, Human papillomavirus
Citation: Hedayat P, Derakhshan M. Bazzal R. A study on the relationship of cervical cancer with vaginal microbiota and trichomoniasis infection; a single center study. J Prev Epidemiol. 2021;6(2):e22. doi: 10.34172/jpe.2021.22.
First Name
Last Name
Email Address
Security code

Abstract View: 71

Your browser does not support the canvas element.

PDF Download: 39

Your browser does not support the canvas element.