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Submitted: 29 Jun 2021
Accepted: 10 Oct 2021
ePublished: 31 Oct 2021
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J Prev Epidemiol. 2022;7(1): e10.
doi: 10.34172/jpe.2022.10
  Abstract View: 67
  PDF Download: 43

Original

A study on the relationship between morphological lesions of lupus nephritis with demographic and biochemical findings

Nasrin Tavassoli 1 ORCID logo, Hamid Nasri 1* ORCID logo, Rohollah Valizadeh 2 ORCID logo

1 Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Minimally Invasive Surgery Research Center, Hazrat-e Rasool General Hospital, Iran University of Medical Sciences, Tehran, Iran and Student Research Committee, Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
Correspondence to: Prof. Hamid Nasri, Email: hamidnasri@yahoo.com, hamidnasri@med.mui.ac.ir

Abstract

Introduction: Lupus nephritis is one of the important aspects of systemic lupus erythematosus (SLE).

Objectives: This study aimed to investigate possible relationship between pathological lesions of lupus nephritis classes and demographic and biochemical findings among patients.

Patients and Methods: This is a cross-sectional study that was conducted on a group of renal biopsy proven lupus nephritis patients using lupus nephritis classification of ISN/RPS 2003. We collected demographic data of all patients including age, gender serum creatinine and 24h proteinuria.

Results: Data of 101 patients, of whom 78 (77.23%) were females and mean age of 33.54±13.15 years. The mean serum creatinine and proteinuria were 1.54±0.88 mg/dL 2502.5±1495.05 mg/d. Based on our data, IV-G (class IV, diffuse lupus nephritis-global) lupus nephritis class was the most common (39.6%) followed by class III (23.8%). The mean crescent and sclerotic glomeruli were 1.66±3.32 and 2.27±5.32, respectively. In this study, 24 hours proteinuria, serum creatinine, activity percent, chronicity percent, crescent and glomerular sclerosis between genders showed no significant differences (P>0.05). The correlation between plasma creatinine and activity was directly positive and significant (r=0.381, P=0.001). In addition, a significant correlation between C1q deposits and glomerular sclerosis (P=0.031) was detected. Accordingly, a significant correlation between IgG deposits and lupus nephritis classification (P=0.025) was seen.

Conclusion: Lupus nephritis of IV-G and III classes of lupus nephritis were most common among patients and higher IgG deposits were observed in patients with IV-G classification. We found a significant correlation between glomerular sclerosis and C1q deposits that could be an indicator of lupus nephritis activity and severity. However, we recommend further studies in this regard.

Keywords: Lupus nephritis, Systemic lupus erythematosus, Proteinuria
Citation: Tavassoli N, Hamid Nasri H, Valizadeh R. A study on the relationship between morphological lesions of lupus nephritis with demographic and biochemical findings. J Prev Epidemiol. 2022;7(1):e10. doi: 10.34172/jpe.2022.10.
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