Submitted: 02 Sep 2021
Accepted: 03 Oct 2021
ePublished: 25 Oct 2021
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J Prev Epidemiol. 2022;7(1): e06.
doi: 10.34172/jpe.2022.06
  Abstract View: 299
  PDF Download: 174


The five-year survival of gastric cancer patients with a focus on its prognostic factors

Abdolhassan Talaiezadeh 1 ORCID logo, Mahsa Noroozi 2* ORCID logo, Pedram Nazari 2* ORCID logo, Ali Ehsanpour 3 ORCID logo

1 Cancer Research Center, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran
2 Student Research Committee, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran
3 Thalassemia and Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
*Corresponding Authors: Correspondence to: Mahsa Noroozi, Email: , Email: noroozi.m@ajums.ac.ir; Correspondence to: Pedram Nazari, Email: , Email: nazari.p@ajums.ac.ir


Introduction: Despite extensive advances in the early diagnosis and treatment of gastric cancer, it is still one of the most common causes of death worldwide. In addition to stage and recurrence, the degree of tumor differentiation affects the survival of patients.

Objectives: The current study was conducted to investigate the prognostic factors and survival rate of patients with gastric cancer.

Patients and Methods: The current prospective study was conducted on patients with gastric cancer from 2010 to 2017 in Imam Khomeini and Apadana hospitals in Ahvaz, Southwest of Iran. For each patient, curative (total or subtotal gastrectomy with D2 lymphadenectomy) or palliative surgery (partial gastrectomy and gastrojejunostomy) were carried out based on clinical indications. Then Cox model was used to analyze factors affecting survival and the Kaplan-Meier test was also utilized to analyze the five-year survival of patients with SPSS version 21.

Results: Around 154 patients with gastric cancer, including 101 males (65.6%), with a mean age of 62.21±13.76 years, were studied. The two- and five-year overall survival (OS) of patients were 57.7% and 28.5%, respectively (median OS=28 m). Lower stage, well-differentiated tumors, absence of metastasis, lack of recurrence, receiving adjuvant chemotherapy and curative surgery were significantly associated with greater OS (P<0.05).

Conclusion: OS rate of patients with gastric cancer undergoing surgery, especially in the ones with high-grade tumors, metastasis and recurrence, is relatively low, hence careful implementation of screening programs should be considered as the most important preventive strategy.

Citation: Talaiezadeh A, Noroozi M, Nazari P, Ehsanpour A. The five-year survival of gastric cancer patients with a focus on its prognostic factors. J Prev Epidemiol. 2022;7(1):e06. doi: 10.34172/jpe.2022.06.
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