Shakiba Hassanzadeh
1 
, Parto Nasri
2 , Mohammadreza Khosravifarsani
3* 1 Nickan Research Institute, Isfahan, Iran
2 Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
3 Cancer Prevention Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract
A 49-year-old patient presented to our clinic with significant weight loss and abdominal pain. She underwent a colonoscopy, which showed a tumor with a size of 10 cm in her transverse colon. The pathology report showed adenocarcinoma. Subsequently, partial right-sided colectomy and bilateral oophorectomy were performed. The repeated pathology evaluation confirmed adenocarcinoma of the colon with metastatic involvement of the right ovary. Upon further evaluation, she was positive for BRAF V600E mutation, which is rare in the Iranian population. She was negative for KRAS and NRAS mutations but was positive for microsatellite instability (MSI). Postoperative chemotherapy was initiated with folinic acid, fluorouracil, and oxaliplatin (FOLFOX). However, during her post-operation period, she developed metastasis to the abdominal wall. Our report highlights the importance of genetically analyzing the tissue samples from these patients to better understand the clinicopathologic features and behavior of these tumors.