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Submitted: 06 Mar 2021
Accepted: 03 Jul 2021
ePublished: 20 Jul 2021
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J Prev Epidemiol. 2021;6(2): e31.
doi: 10.34172/jpe.2021.31
  Abstract View: 59
  PDF Download: 39

Review

The relationship between COVID-19 and blood vitamin C; a systematic review study

Sadeq Hosseinpour 1 ORCID logo, Nasrin Moradi 2, Reyhane Izadi 3, Shahrzad Shadabi 4, Raheleh Behzadi 5, Masoumeh Sadat Mousavi 6,1*, Abuzar Shirazi 1 ORCID logo, Ebrahim Moayedi 1 ORCID logo

1 Department of Epidemiology and Biostatistics, School of Public Health, Shahrekord University of Medical Sciences, Shahrekord, Iran
2 PhD Student, School of Medical Management and Information, Iran University of Medical Sciences, Tehran, Iran
3 Department of Health Care Management and Information Sciences, Shiraz University Medical Sciences, Shiraz, Iran
4 Department of Medical Virology, Kerman University of Medical Sciences, Kerman, Iran
5 Department of biology, Division of Genetic, Nourdanesh University of Meymeh, Meymeh, Iran
6 Modeling in Health Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
7 Department of Epidemiology and Biostatistics, School of Public Health, Shahrekord University of Medical Sciences, Shahrekord, Iran
Correspondence to: Masoumeh Sadat Mousavi, Email: mousavi68.ma@yahoo.com, ma@skuns.ac.ir

Abstract

Introduction: The rapid worldwide spread of COVID-19 has caused a global health crisis. Unfortunately, no vaccine or special antiviral drug has been developed against COVID-19 to date, symptomatic supportive care has been the most common treatment.

Objectives: the purpose of this systematic review aims to provide a timely, rigorous, and continuously updated summary of the available evidence on the role of vitamin C in treating patients with COVID-19.

Methods: In this review, we identified studies published in 2020 that describe on the relationship between COVID-19 and vitamin C. We searched PubMed, Google Scholar, Scopus, Magiran, SID and Web of Science for research articles published up to 23 December 2020 using the keywords of vitamin C, COVID-19, SARS-COV-2 and coronavirus 2.

Results: At the initial stage of screening, 181articles were excluded after reviewing the title and removing irrelevant and duplicate titles, 52 articles were selected to review the abstract. After reviewing the abstract (or in articles without abstracts after reviewing the original text), nine articles were finally considered suitable for this purpose and were reviewed and finalized. Vitamin C is a pivotal component of the immune system, with proven antioxidant, cytokine storm suppressor and anti-inflammatory properties and has been tested in numerous studies for its role in severe sepsis and ICU care, especially when used as a continuous high-dose intravenous infusion. In addition, some studies indicated high-dose intravenous vitamin C treatment was associated with fewer days on mechanical ventilation, shorter ICU stay, and earlier recovery compared to the average length of mechanical ventilation, disease duration, and ICU stay in critical COVID-19 patients.

Conclusion: Vitamin C can significantly improve clinical symptoms, inflammatory response, immune and organ function in COVID-19 patients. In patients affected with COVID-19, high-dose intravenous vitamin C is expected to improve pulmonary function and reduce mortality for patients with COVID-19 and can be beneficial in aspects of inflammatory response, immune and organ function for aggravation of COVID-19 patients, however further clinical trials are necessary.

Keywords: COVID-19, Coronavirus 2019, SARS-CoV-2, Vitamin C, Ascorbic acid
Citation: Hosseinpour S, Moradi N, Izadi R, Shadabi S, Behzadi R, Mousavi MS, Shirazi A, Moayedi E. The relationship between COVID-19 and blood vitamin C; a systematic review study. J Prev Epidemiol. 2021;6(2):e31. doi: 10.34172/ jpe.2021.31.
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