Introduction: Coronary artery diseases (CADs) are a global health issue. In addition, several researchers have reported a correlation between serum vitamin D levels and different aspects of cardiovascular diseases. It has been reported that vitamin D can modulate atherothrombosis.
Objectives: This study aimed to investigate the correlation between 25-hydroxyvitamin D and CAD severity.
Patients and Methods: This is a cross-sectional study. The study sample consisted of patients undergoing elective coronary angiography. To assess 25-hydroxyvitamin D levels, fasting samples were collected from patients. Patients were included in this study based on the number of involved coronary vessels and SYNTAX classification.
Results: The serum levels of 25-hydroxyvitamin D were significantly lower in the group of patients with CAD and cardiovascular disease than in the control group (P<0.001). This study showed, severe vitamin D deficiency caused significantly higher SYNTAX scores (P<0.001).
Conclusion: The results of our study showed, vitamin D deficiency might have an essential relationship with the severity and incidence of CAD; however, we recommend further studies to investigate the preventing effects of vitamin D supplementation, primarily through intervention studies.