Podocyte infolding glomerulopathy is a rare form of glomerular disease that can lead to proteinuria, chronic kidney disease, and end-stage renal disease. While the cause of podocyte infolding glomerulopathy is currently unknown, it is thought to be related to abnormalities in the glomerular basement membrane (GBM) structure and function. In this condition, the podocytes fold inward and form pockets or invaginations. This can lead to damage and scarring of the glomeruli, impairing kidney function. Diagnosis is typically made through clinical and laboratory tests, and treatment focuses on managing symptoms and slowing the progression of chronic kidney disease. Further research is needed to understand the pathophysiology of podocyte infolding glomerulopathy better and develop more effective treatments for this condition. Symptoms of podocyte infolding glomerulopathy may include proteinuria, hematuria, and decreased kidney function. Treatment options may include medications to control blood pressure and reduce proteinuria and immunosuppressive therapy to reduce inflammation and slow the progression of kidney damage.