Esmat Aghadavoud
1, Hamid Nasri
2, Masoud Amiri
3,4*1 Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
2 Nickan Research Institute, Isfahan, Iran
3 Department of Epidemiology and Biostatistics, Shahrekord University of Medical Sciences, Shahrekord, Iran
4 Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
Abstract
Diabetic kidney disease is a main cause of end-stage renal disease (ESRD), therefore, it is important to understand the molecular mechanism underlying diabetic kidney disease. Todays, various factors such as hemodynamic changes, molecular signaling and metabolic pathways have been shown to be involved in its pathogenesis. Excessive glucose influx stimulates cellular signaling pathways, containing advanced glycation end-products (AGEs), oxidative stress conditions, Rho-kinase, the diacylglycerol (DAG)-protein kinase C (PKC) pathway, polyol pathway and hexosamine pathway. In hyperglycemic condition, these factors cooperate with other aggravating factors. Then activated inflammatory processes lead to the development of glomerulosclerosis. The aim is to describe understanding of the signaling pathways in diabetic kidney disease.