Seyed Yousef Mojtahedi
1,2 
, Parisa Ashournia
3, Paniz Pourpashang
1.2* 1 Department of Pediatric Nephrology, Bahrami Hospital, school of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2 Pediatric Chronic Kidney Disease Research Center, Gene, Cell and Tissue Research Institute, Tehran University of Medical Sciences, Tehran, Iran
3 Department of Allergy and Clinical Immunology, Bahrami Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Abstract
Numerous studies have shown that patients with IgA nephropathy (IgAN) exhibit a range of systemic inflammatory indicators that correlate with clinical outcomes. Elevated neutrophil-to-lymphocyte ratios and systemic immune inflammation index scores have been associated with poorer renal survival and strengthened risk of progression to end-stage renal disease (ESRD). The relationship between systemic inflammation and IgAN progression provides valuable insights into potential therapeutic strategies and prognostic implications for cases suffering from this disease. However, this tool has some limitations which should be respected following its application.