Salt wasting syndrome; a review on current findings and new concepts 

Abstract

Cerebral/renal salt wasting is a disease category that has evolved as a medical entity by differentiation of syndrome of inappropriate ADH (SIADH) secretion. It is characterized by depletion of extracellular volume and thereby negative sodium balance. While there is a great overlap in the clinical and laboratory characteristics of SIADH and salt wasting; the therapeutic interventions are contradictory and they include limiting water intake in SIADH and providing for free water and salt intake in salt wasting to overcome the tendency to develop hypernatremia. 

Keywords: Salt wasting, syndrome of inappropriate ADH secretion (SIADH), Cerebral/renal salt wasting, Alzheimer’s disease, Hyponatremia, Hypernatremia