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Submitted: 07 Nov 2019
Accepted: 14 Dec 2020
ePublished: 20 Dec 2019
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J Prev Epidemiol. 2019;4(2): e19.
  Abstract View: 765
  PDF Download: 388

Original

Frequency of prolactinoma in surgical specimens of pituitary adenoma in patients referred to Alzahra hospital in Isfahan (2012–2019)

Maryam Derakhshan 1 ORCID logo, Azar Baradaran 1*, Alireza Zafarian 2* ORCID logo, Shaghayegh Ferdowsian 2, Mohammadhatef Sadri 2, Ashraf Aminorroaya 3, Pegah Hedayat 1, Mitra Heidarpour 1, Shahnaz Eskandari 1, Azar Naimi 1, Parvin Rajabi Dehnavi 1, Amirhossein Pezeshki 1

1 Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran
2 Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3 Department of Internal Medicine, Isfahan, University of Medical Sciences, Isfahan, Iran
*Corresponding Authors: Email: azarbaradaran@med.mui.ac.ir; Email: md.zafarian@gmail.com

Abstract

Introduction: Prolactinoma is a common subtype of the pituitary adenomas. Epidemiology study of the distribution of this tumor is necessary to assess the burden of the disease.

Objectives: The aim of this study is to describe the prevalence of prolactinoma in pituitary adenoma patients in Isfahan.

Patients and Methods: This retrospective cross-sectional study included all pituitary adenomas patients who underwent transsphenoidal tumor resection during 2012–2019. The biopsy samples of these patients were conducted for immunohistochemistry (IHC) staining and were blindly interpreted.

Results: Around188 eligible patients with mean age of 46.05 ± 9.5 including 96 female patients and 92 male patients were enrolled in the study. Prolactinoma was seen in 76 (40.1%) of patients, with 44 female patients with a mean age of 42.1 years and 32 male patients with a mean age of 51.8 years. Women were significantly younger.

Conclusion: Prolactinoma is a common subtype of pituitary adenoma since this disease is more frequent in female patients. Although the mean age of diagnosis in female patients is lower, the size and intensity are greater in male patients.


Citation: Derakhshan M, Baradaran A, Zafarian A, Ferdowsian S, Sadri M, Aminorroaya A. Frequency of prolactinoma in surgical specimens of pituitary adenoma in patients referred to Alzahra hospital in Isfahan (2012–2019). J Prev Epidemiol. 2019;4(2):e19. doi:10.34172/jpe.2019.19.
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