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J Prev Epidemiol. 2019;4(2): e20.
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Evaluation of the frequency of gonadotroph adenoma with immunohistochemistry among surgical specimens of pituitary adenoma in Isfahan, Iran

Azar Baradaran 1* ORCID logo, Azar Naiimi 1 ORCID logo, Shaghayegh Ferdowsian 2 ORCID logo, Alireza Zafarian 2* ORCID logo, Fatemeh Roustaii 2 ORCID logo, Mohammadhatef Sadri 2 ORCID logo, Ashraf Aminorroaya 3 ORCID logo, Pegah Hedayat 1 ORCID logo, Mitra Heidarpour 1 ORCID logo, Shahnaz Eskandari 1 ORCID logo, Maryam Derakhshan 1 ORCID logo, Parvin Rajabi Dehnavi 1 ORCID logo, Amirhossein Pezeshki 1 ORCID logo

1 Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran
2 Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3 Department of Internal Medicine, Isfahan, University of Medical Sciences, Isfahan, Iran
*Corresponding Authors: Email: azarbaradaran@med.mui.ac.ir; Email: md.zafarian@gmail.com

Abstract

Introduction: Gonadotroph adenomas are a type of pituitary adenomas. It is now clear that these adenomas are relatively more frequent than previously thought.

Objectives: The aim of the present study is to investigate the prevalence of gonadotropin pituitary adenomas.

Patients and Methods: Specimens of surgically resected of 188 patients with pituitary adenomas were collected. In this study chromogranin A was used for immunostaining and identifying gonadotroph adenomas.

Results: Immunostaining turned out to be positive in 93 specimens out of 188. Data analysis indicated a correlation between gender and gonadotropin adenomas prevalence (P = 0.041), since of 93 positive specimens, 57.6% were males.

Conclusion: Gonadotroph cells are commonly seen in pituitary adenoma patients. Men are at higher risk of developing this type of tumor.


Citation: Baradaran A, Naimi A, Ferdowsian S, Zafarian A, Sadri M, Aminorroaya A, et al. Evaluation of the frequency of gonadotroph adenoma with immunohistochemistry among surgical specimens of pituitary adenoma in Isfahan, Iran. J Prev Epidemiol. 2019;4(2):e20.
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