Abstract
Introduction: Helicobacter pylori is associated with pathogenesis of various gastrointestinal diseases.
Prevalence of this infection is different with high heterogeneity around the world. To investigate
seroprevalence of H. pylori IgG among Iranian general population during 2008-2017 as a 10-year
epidemiological interval using previously published documents. This is an ecological study based on
the related data previously published documents in English and Persian.
Materials and Methods: Data were collected through the international databases Google Scholar,
PubMed and Web of Science, as well as the local Persian databases Magiran, SID and Irandoc. Excel
2013 and STATA 14 were used to analyze the data. After an exact search 14 populations from 10
studies, 10 cities and 9 provinces were used. The total number of samples was 10470.
Results: The funnel plot showed that 5 populations had significantly lower prevalence than the
average, seven populations had significantly higher prevalence than the average, and two populations
were inside the funnel. The weightless average was 63.8%. The forest plot showed that the pooled
prevalence of H. pylori in Iran is significantly more than 50%. The contour plot and ecological map
are also shown.
Conclusion: The pooled prevalence of H. pylori IgG seropositivity in Iran during recent 10 years was
63.8% (weightless average) which was significantly higher than 50%. Khorramabad and Babol had
the lowest prevalence (43%) whereas Izeh had the highest prevalence (76%) followed by Neyshabur.