TM6SF2 E167K variant and deterioration on hepatitis disease and hepatocellular carcinoma; a molecular explanation

Abstract

Hepatic disorder is a common problem in medicine. The serious liver diseases such as hepatitis and hepatocellular carcinoma are the present public health problem worldwide. The effect of genetic background on the liver disease severity is very interesting. Of several genetic underlying factors, the TM6SF2 polymorphism is widely mentioned of the clinical importance. The existence of TM6SF2 E167K variant is reported for the relationship with the severity of hepatitis and hepatocellular carcinoma diseases. In this article, the authors perform a molecular structure analysis by standard quantum calculation technique. The molecular change in the TM6SF2 E167K variant is observed and can explained for the deterioration of liver diseases seen in this genetic variant

Keywords: Hepatitis, Hepatocellular carcinoma, TM6SF2 polymorphism, Liver disease