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Submitted: 04 Jun 2021
Accepted: 07 Oct 2021
ePublished: 19 Nov 2021
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  Abstract View: 141

Review

Metabolomics in lupus; opportunities and challenges

Sara Afshari 1 ORCID logo, Narges Kalhor 1 ORCID logo, Seyed Mojtaba Alavi 1 ORCID logo, Seyed Mohammad Hashem Montazeri 1 ORCID logo, Maryam Masoumi 2* ORCID logo

1 Student Research Committee, School of Medicine, Qom University of Medical Sciences, Qom, Iran
2 Clinical Research Development Center, Shahid Beheshti Hospital, Qom University of Medical Sciences, Qom, Iran
Correspondence to: Maryam Masoumi, Email: mmasoomi@muq.ac.ir

Abstract

Systemic lupus erythematosus (SLE) is characterized by an inappropriate autoimmune response to self-antigens. This disease is a heterogeneous autoimmune disease that shows variable clinical course. Metabolomics employs advanced analytical chemistry techniques to comprehensively measure many small molecule metabolites in biological cells and tissues. Metabolites are downstream of translation processes and are thought to be associated with disease phenotypes. This technology is recognized as a powerful tool with excellent potential for detecting prognostic and diagnostic biomarkers in rheumatic diseases. In this review; we summarized the recent available results of studies on metabolomics in lupus and the importance of metabolomics in the finding of diagnostic and prognostic biomarkers was investigated.
Keywords: Biological samples, Biomarkers, Metabolomics, Personalized medicine, Systemic lupus erythematosus, Autoimmune diseases
Citation: Afshari S, Kalhor N, Alavi SM, Montazeri SMH , Masoumi M. Metabolomics in lupus; opportunities and challenges. J Prev Epidemiol. 2022;7(1):exx. doi: 10.34172/jpe.2022. xx.
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