Society of Diabetic Nephropathy Prevention Journal of Preventive Epidemiology 2476-3934 4 2 2019 07 01 Mechanisms of Helicobacter pylori-induced gastric mucosal injury e27 e27 EN Mohammad Bahadoram Bijan Keikhaei Mohammad-Reza Mahmoudian-Sani Kosar Alikhani Motahareh Motiee Ammar Helalinasab Maedeh Barahman Journal Article 2019 09 29 2019 11 10 Helicobacter pylori is a common pathogenic microorganism which is able to colonize in harsh acidic environment of the stomach. It also plays an important role in developing gastric cancer (GC) by causing inflammation, epigenetic changes in cancer-related genes, and disturbance in life cycle of cells. Besides, GC is the fourth most common cause of cancer-related mortality in the world. There is still no consensus regarding the eradication of H. pylori and its effects in terms of preventing gastric lesion or atrophy progression. The main purpose of this review was to evaluate factors shaping H. pylori colonization into gastric epithelial cells and then normal gastric mucosa progression to GC.