Society of Diabetic Nephropathy Prevention Journal of Preventive Epidemiology 2476-3934 1 2 2016 05 10 Predictors of hemorrhagic complications after ultrasoundguided nonfocal renal biopsy e11 EN Amy Deipolyi Suvranu Ganguli Fabio Leonardo Peter F. Hahn Chieh Suai Tan Ashraf Thabet Elkan F. Halpern Peter R. Mueller Journal Article 2016 01 28 2016 04 04 Introduction: Ultrasound-guided non-focal renal biopsy (USNFRB) is a well-accepted procedure performed in the renal cortex to investigate medical renal disease or renal transplant rejection. Objectives: The purpose of this study was to identify the hemorrhagic complication rate for a large cohort of patients after radiologist-performed USNFRB and to identify risk factors. Patients and Methods: For this Institutional Review Board-approved retrospective review, all patients who underwent USNFRB from January 2001 to September 2012 were identified using a departmental database, and reviewed the electronic chart for demographics, laboratory workup, medications, procedural details, and complications. The impact of these variables on the likelihood of having a bleeding complication that either did (major) or did not (minor) require further intervention was assessed, using Fisher exact and Student’s t tests, and multiple logistic regression. Results: Of 570 USNFRBs performed by radiologists, 26 (4.6%) resulted in hemorrhagic complications, 15 of which were major and 11 minor. Neither age, gender, race, nor size of biopsy needle differed among patients with and without bleeding complications (P > 0.05). When assessing the impact of coagulation and renal function laboratory measures, low estimated glomerular filtration rate (eGFR) was the strongest predictor of bleeding complication (P = 0.03). Conclusion: USNFRB is a relatively safe procedure, with less than 5% resulting in bleeding complications. Low eGFR is the strongest predictor of hemorrhagic complication, and is likely the most helpful variable in triaging patients during pre-procedure workup.