Society of Diabetic Nephropathy Prevention Journal of Preventive Epidemiology 2476-3934 8 1 2023 03 01 Metabolomics in lupus; opportunities and challenges e19150 e19150 10.34172/jpe.2022.19150 EN Sara Afshari https://orcid.org/0000-0002-2426-8533 Narges Kalhor https://orcid.org/0000-0002-9407-8081 Seyed Mojtaba Alavi https://orcid.org/0000-0002-0493-8480 Seyed Mohammad Hashem Montazeri https://orcid.org/0000-0002-6874-5215 Maryam Masoumi https://orcid.org/0000-0003-2635-2656 Journal Article 10.34172/jpe.2022.19150 2021 06 04 2021 10 07 Systemic lupus erythematosus (SLE) is characterized by an inappropriate autoimmune response to self-antigens. This disease is a heterogeneous autoimmune disease that shows variable clinical course. Metabolomics employs advanced analytical chemistry techniques to comprehensively measure many small molecule metabolites in biological cells and tissues. Metabolites are downstream of translation processes and are thought to be associated with disease phenotypes. This technology is recognized as a powerful tool with excellent potential for detecting prognostic and diagnostic biomarkers in rheumatic diseases. In this review; we summarized the recent available results of studies on metabolomics in lupus and the importance of metabolomics in the finding of diagnostic and prognostic biomarkers was investigated.