Society of Diabetic Nephropathy Prevention Journal of Preventive Epidemiology 2476-3934 7 1 2022 01 01 A review of the reasons for high prevalence and rapid progression of COVID-19 in men e03 e03 10.34172/jpe.2022.03 EN Neda Taghizabet https://orcid.org/0000-0001-7128-319X Fatemeh Rezaei-Tazangi https://orcid.org/0000-0003-1402-6482 Hossein Roghani‐Shahraki https://orcid.org/0000-0001-9530-5744 Journal Article 10.34172/jpe.2022.03 2021 07 21 2021 10 14 Previous studies have demonstrated a relationship between gender and COVID-19 outcomes. In addition, this is confirmed that men have more danger of progressing an acute type of the illness than women, specifies the significance of miscellaneous data related to male and female patients with COVID-19. In other words, some factors like hormonal levels and immune function may interact with each other. A perception of the fundamental reasons for gender diversities in COVID-19 patients can beget a chance for disease prevention and faster treatment. The present study evaluates the role of gender in the incidence and progression of the COVID-19 disease. It has been explained that how gender affects angiotensin-converting enzyme 2 (ACE2), which is a basic factor for the COVID-19 pathogenesis introducing the sex diversities in platelet function, immune reactions and how sex hormones affect immune functions, also the effect of androgens on transmembrane protein serine protease 2 (TMPRSS2) receptor in COVID-19 patients was investigated.