Society of Diabetic Nephropathy Prevention Journal of Preventive Epidemiology 2476-3934 8 1 2023 03 01 Association of serum vitamin D levels with coronary artery angiographic findings; A cross-sectional study e26181 e26181 10.34172/jpe.2023.26181 EN Naser Aslanabadi https://orcid.org/0000-0003-2274-1494 Nader Jangioskouei https://orcid.org/0000-0003-2761-2034 Negar Jafari https://orcid.org/0000-0002-6249-2587 Azin Pakmehr https://orcid.org/0000-0003-3072-212X Amirreza Khalaji https://orcid.org/0000-0001-9909-1683 Azam Esmailnejad https://orcid.org/0000-0003-3309-6793 Mohammadreza Moslemi https://orcid.org/0000-0002-0403-7156 Shahin Khabbazi Journal Article 10.34172/jpe.2023.26181 2022 09 09 2023 01 14 Introduction: Coronary artery diseases (CADs) are a global health issue. In addition, several researchers have reported a correlation between serum vitamin D levels and different aspects of cardiovascular diseases. It has been reported that vitamin D can modulate atherothrombosis. Objectives: This study aimed to investigate the correlation between 25-hydroxyvitamin D and CAD severity. Patients and Methods: This is a cross-sectional study. The study sample consisted of patients undergoing elective coronary angiography. To assess 25-hydroxyvitamin D levels, fasting samples were collected from patients. Patients were included in this study based on the number of involved coronary vessels and SYNTAX classification. Results: The serum levels of 25-hydroxyvitamin D were significantly lower in the group of patients with CAD and cardiovascular disease than in the control group (P<0.001). This study showed, severe vitamin D deficiency caused significantly higher SYNTAX scores (P<0.001). Conclusion: The results of our study showed, vitamin D deficiency might have an essential relationship with the severity and incidence of CAD; however, we recommend further studies to investigate the preventing effects of vitamin D supplementation, primarily through intervention studies.