Society of Diabetic Nephropathy Prevention Journal of Preventive Epidemiology 2476-3934 2 2 2017 07 01 Molecular signaling pathways of diabetic kidney disease; new concepts e09 e09 EN Esmat Aghadavoud Hamid Nasri Masoud Amiri Journal Article 2017 02 18 2017 04 02 Diabetic kidney disease is a main cause of end-stage renal disease (ESRD), therefore, it is important to understand the molecular mechanism underlying diabetic kidney disease. Todays, various factors such as hemodynamic changes, molecular signaling and metabolic pathways have been shown to be involved in its pathogenesis. Excessive glucose influx stimulates cellular signaling pathways, containing advanced glycation end-products (AGEs), oxidative stress conditions, Rho-kinase, the diacylglycerol (DAG)-protein kinase C (PKC) pathway, polyol pathway and hexosamine pathway. In hyperglycemic condition, these factors cooperate with other aggravating factors. Then activated inflammatory processes lead to the development of glomerulosclerosis. The aim is to describe understanding of the signaling pathways in diabetic kidney disease.