Society of Diabetic Nephropathy Prevention Journal of Preventive Epidemiology 2476-3934 2 2 2017 07 01 Impact of proton pump inhibitors on renal function and structure; new concepts e11 e11 EN Mahrang Hedaiaty Arman Amiri Masoud Amiri Journal Article 2017 01 19 2017 04 14 Proton pump inhibitors (PPIs) such as omeprazole, pantoprazole, esomeprazole and lansoprazole are the most popular therapies for reflux disease and heartburn. Applications of PPIs are commonly safe and well-accepted by physicians, with an adverse effect occurring at a rate of about three percent. The common side effects are dizziness, constipation, headaches, diarrhea and cutaneous responses. PPIs can influence in all cells of body that are related to deadly diseases such as heart attacks, kidney disease and dementia. Some research studies have found that PPIs were related to an inflammatory process in the kidneys as acute interstitial nephritis. This review will emphasis on conducted researches about adverse effects of PPIs on the kidney.