Society of Diabetic Nephropathy Prevention Journal of Preventive Epidemiology 2476-3934 10 2 2025 06 30 Evaluation of measles immunity in patients with COVID-19 infection in Isfahan e39259 e39259 10.34172/jpe.2025.39259 EN Morteza Pourahmad https://orcid.org/0000-0003-1946-2953 Sara Nasirharandi Mahnaz Momenzadeh https://orcid.org/0000-0001-7136-3069 Elahe Nasri Shahzad Baradaran Kiana Shahzamani Fatemeh Nikoukar Zahra Doozandeh Ameneh Arab Chadegani Journal Article 10.34172/jpe.2025.39259 2024 10 13 2024 12 20 Introduction: COVID-19 has become a widespread epidemic worldwide. The different vaccines may play a protective effect on illness intensity. Therefore, in this study, we aimed to evaluate measles IgG titer in COVID-19 patients and correlate it with disease severity. Objectives: We evaluated the measles IgG titer and intensity of illness with measles-specific immunoglobulin G (IgG) in COVID-19 patients. Patients and Methods: This cross-sectional study was conducted on 72 patients infected with COVID-19 with high and low severity. An enzyme-linked immunosorbent assay (ELISA) was used to detect the measles-mumps-rubella (MMR) vaccine’s serum IgG antibody in COVID-19 patients. Then, the correlation of disease intensity and IgG level was evaluated using one-way analysis variance (ANOVA) in SPSS 26. Results: In this study, there was a significant difference between illness intensity and IgG serum level of MMR in experimental groups (P<0.05). Conclusion: There is a significant relationship between the severity of COVID-19 and measles IgG titer.