Society of Diabetic Nephropathy Prevention Journal of Preventive Epidemiology 2476-3934 11 2 2026 06 30 Systemic inflammatory response index in IgA nephropathy; a review to recent findings e39273 e39273 10.34172/jpe.2025.39273 EN Seyed Yousef Mojtahedi https://orcid.org/0000-0002-6231-2662 Parisa Ashournia Paniz Pourpashang https://orcid.org/0009-0001-2341-4965 Journal Article 10.34172/jpe.2025.39273 2025 07 13 2025 12 03 Numerous studies have shown that patients with IgA nephropathy (IgAN) exhibit a range of systemic inflammatory indicators that correlate with clinical outcomes. Elevated neutrophil-to-lymphocyte ratios and systemic immune inflammation index scores have been associated with poorer renal survival and strengthened risk of progression to end-stage renal disease (ESRD). The relationship between systemic inflammation and IgAN progression provides valuable insights into potential therapeutic strategies and prognostic implications for cases suffering from this disease. However, this tool has some limitations which should be respected following its application.