Society of Diabetic Nephropathy Prevention Journal of Preventive Epidemiology 2476-3934 11 1 2026 01 01 Kawasaki-like disease associated with COVID-19 (Kawa-COVID-19); an overview of recent evident e39274 e39274 10.34172/jpe.2025.39274 EN Paniz Pourpashang https://orcid.org/0009-0001-2341-4965 Journal Article 10.34172/jpe.2025.39274 2025 07 13 2025 08 16 Kawa-COVID-19 represents a new pediatric inflammatory syndrome associated with SARS-CoV-2 infection that mimics but is distinct from classic Kawasaki disease. Kawasaki-like disease associated with COVID-19 is a serious inflammatory condition that emerged during the COVID-19 pandemic. In Kawa-COVID-19, autoantibodies specifically target endothelial cells by recognizing both constitutive and induced endothelial antigens, often due to molecular mimicry, leading to complement activation, immune-mediated cytotoxicity, and endothelial dysfunction. These processes collectively contribute to vascular inflammation, coagulopathy, and the multisystem manifestations of the disease. This description incorporates the current evidence on how autoantibodies target endothelial cells in Kawa-COVID-19, highlighting key immunopathological mechanisms underlying vascular injury. Additionally, acute kidney injury, in this disease can be prerenal due to hypoperfusion or heart failure or intrinsic renal AKI from tubulointerstitial nephritis, hemolytic uremic syndrome, immune-complex nephropathy, or causes related to Kawasaki disease shock syndrome.