Society of Diabetic Nephropathy Prevention Journal of Preventive Epidemiology 2476-3934 11 2 2026 07 01 Solitary myofibroma of the oral cavity; a rare case report e39314 e39314 10.34172/jpe.39314 EN Saman Abbasi https://orcid.org/0009-0006-6506-1826 Parto Nasri https://orcid.org/0000-0002-9596-8860 Maryam Mohebiniya https://orcid.org/0000-0001-6691-0128 Salar Nasr Esfahani https://orcid.org/0000-0003-2290-3588 Ehsan Momeni https://orcid.org/0000-0002-1457-5230 Journal Article 10.34172/jpe.39314 2025 12 08 2026 05 20 Myofibroma is an uncommon benign neoplasm of myofibroblastic origin that primarily affects children and adolescents. While it most frequently arises in the skin and subcutaneous tissues, its occurrence in the oral cavity, particularly in the buccal soft tissue is exceptionally rare. Owing to its clinical similarity to other benign spindle-cell lesions, such as irritation fibroma and neural tumors, establishing an accurate diagnosis can be challenging. This report describes a rare case of solitary oral myofibroma presenting as a buccal soft tissue swelling of the left mandible. The clinical, radiographic, histopathologic, and immunohistochemical features are presented, together with a discussion on differential diagnosis, management, and prognosis.