Society of Diabetic Nephropathy Prevention Journal of Preventive Epidemiology 2476-3934 4 2 2019 07 01 Evaluation of the frequency of gonadotroph adenoma with immunohistochemistry among surgical specimens of pituitary adenoma in Isfahan, Iran e20 e20 EN Azar Baradaran https://orcid.org/0000-0001-7058-6367 Azar Naiimi https://orcid.org/0000-0002-7717-9112 Shaghayegh Ferdowsian https://orcid.org/0000-0001-9790-9189 Alireza Zafarian https://orcid.org/0000-0002-6021-6028 Fatemeh Roustaii https://orcid.org/0000-0002-1816-0788 Mohammadhatef Sadri https://orcid.org/0000-0001-9996-9046 Ashraf Aminorroaya https://orcid.org/0000-0002-7550-1198 Pegah Hedayat https://orcid.org/0000-0001-5046-0388 Mitra Heidarpour https://orcid.org/0000-0002-3332-2933 Shahnaz Eskandari https://orcid.org/0000-0002-3332-2933 Maryam Derakhshan https://orcid.org/0000-0003-0517-2111 Parvin Rajabi Dehnavi https://orcid.org/0000-0002-8278-1415 Amirhossein Pezeshki https://orcid.org/0000-0002-3271-7706 Journal Article 2019 10 11 2019 12 10 Introduction: Gonadotroph adenomas are a type of pituitary adenomas. It is now clear that these adenomas are relatively more frequent than previously thought. Objectives: The aim of the present study is to investigate the prevalence of gonadotropin pituitary adenomas. Patients and Methods: Specimens of surgically resected of 188 patients with pituitary adenomas were collected. In this study chromogranin A was used for immunostaining and identifying gonadotroph adenomas. Results: Immunostaining turned out to be positive in 93 specimens out of 188. Data analysis indicated a correlation between gender and gonadotropin adenomas prevalence (P = 0.041), since of 93 positive specimens, 57.6% were males. Conclusion: Gonadotroph cells are commonly seen in pituitary adenoma patients. Men are at higher risk of developing this type of tumor.