Society of Diabetic Nephropathy Prevention Journal of Preventive Epidemiology 2476-3934 5 2 2020 07 01 Assessing the relationship between infantile colic and parental migraine in infants aged 4 to 12 weeks in Urmia e22 e22 10.34172/jpe.2020.22 EN Ezatolah Abbasi https://orcid.org/0000-0002-1117-380X Ahad Ghazavi https://orcid.org/0000-0003-0829-3525 Kamran Dehghan https://orcid.org/0000-0001-6552-7477 Mahsa Soleimani Journal Article 10.34172/jpe.2020.22 2020 04 19 2020 06 18 Introduction: Infantile colic affects 5% to 19% of infants. Objectives: This study aimed to investigate the relationship between infantile colic crying and migraine in parents. Patients and Methods: In this study, the infants referred to Urmia health centers with 4 to 12 weeks old were investigated. According to the definition of infantile colic and questioning the parents, those infants were identified who cried at least three hours a day, at least three days a week, for at least 3 weeks. By filling out a questionnaire on infantile colic and migraine in parents, the relationship between migraine in parents and colic in infants was examined. Results: In this study, 195 infants aged 4 to 12 weeks were included. Around 107 (54.9%) were male. The mean age of infants was 6.50 ± 2.10 weeks. Of the 195 infants, 65 (33.3%) had colic, 32 (49.2%) were male and 33 (50.8%) were female (P = 0.26). Around 47 (24.1%) of parents had migraine and 148 (75.9%) had no history of migraine. Of 65 infants with colic, 38 (58.5%) had migraine parents and 27 (41.5%) had no history of parental migraine. Of 130 infants without colic, 9 (6.9%) of the parents had a history of migraine and 121 (93.1%) of them had no migraine (P = 0.001). Of 65 infants with colic, 31 of the mothers had migraine, since of 130 infants without colic, none of their mothers complained about migraine (P = 0.001). Conclusion: Infantile colic was significantly associated with parental migraine and it could be an early sign of disease in infants.