Psychological problems such as negatively affect quality of life in hemodialysis patients and their response to treatment. In present study we reviewed prevalence of depression among Iranian end-stage renal diseases patients who were under hemodialysis. A narrative review of the literature was undertaken between May 2016 and July 2016, which involved searching several electronic sources including Cochrane Library, Science Direct, Elsevier, Web of Knowledge, EMBASE, PubMed, Medline, Scopus, IranMedex, Scientific Information Database, ISC, Google, Google Scholar and Yahoo. The following keywords were used; chronic kidney disease, end-stage renal disease, psychological issue, depression, dialysis, hemodialysis, renal replacement therapy, patients, Iran. We included 15 studies for this review. Most studies included in present study used self-reported questionnaire to measuring depression. According to finding of present study, depression prevalence was between 39.2% and 90.2%. Depression has several adverse effects on end-stage renal disease patients. Present review study revealed that depression is common among Iranian hemodialysis patients. All healthcare workers should be aware of this and planed for prevention and management.